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KMID : 1161420160190040346
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Journal of Medicinal Food
2016 Volume.19 No. 4 p.346 ~ p.352
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Black Raspberry Extract Increased Circulating Endothelial Progenitor Cells and Improved Arterial Stiffness in Patients with Metabolic Syndrome: A Randomized Controlled Trial
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Jeong Han-Saem
Kim So-Hyeon
Hong Soon-Jun
Choi Seung-Cheol
Choi Ji-Hyun
Kim Jong-Ho
Park Chi-Yeon
Cho Jae-Young
Lee Tae-Bum
Kwon Ji-Wung
Joo Hyung-Joon
Park Jae-Hyoung
Yu Cheol-Woong
Lim Do-Sun
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Abstract
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Administration of black raspberry (Rubus occidentalis) is known to improve vascular endothelial function in patients at a high risk for cardiovascular (CV) disease. We investigated short-term effects of black raspberry on circulating endothelial progenitor cells (EPCs) and arterial stiffness in patients with metabolic syndrome. Patients with metabolic syndrome (n?=?51) were prospectively randomized into the black raspberry group (n?=?26, 750?mg/day) and placebo group (n?=?25) during the 12-week follow-up. Central blood pressure, augmentation index, and EPCs, such as CD34/KDR+, CD34/CD117+, and CD34/CD133+, were measured at baseline and at 12-week follow-up. Radial augmentation indexes were significantly decreased in the black raspberry group compared to the placebo group (?5%?±?10% vs. 3%?±?14%, P?
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KEYWORD
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augmentation index, black raspberry, central blood pressure, endothelial progenitor cells, metabolic syndrome
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